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Clinical Review

Sudden collapses in the heat in patients on angiotensin type 2 receptor blockers

Submitted: 12 March 2013
Revised: 3 September 2013
Accepted: 17 October 2013
Published: 24 May 2014

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Author(s) : Radford PJ.

Peter Radford

Citation: Radford PJ.  Sudden collapses in the heat in patients on angiotensin type 2 receptor blockers. Rural and Remote Health (Internet) 2014; 14: 2578. Available: (Accessed 21 October 2017)


Context:  A clinical case report is presented of some patients taking angiotensin type 2 receptor blockers (AT2RB) who collapsed without warning whilst being active outdoors in the heat.
Issues:  It is not possible to recognise hypotension due to the heat by testing in a controlled environment such as a doctor’s office. Many people taking AT2RBs may be thus misdiagnosed and inappropriately treated.
Lessons learned:  Sudden collapse in a patient on AT2RB who is active in the heat should alert the physician to the possible cause of extreme sensitivity to low-grade volume depletion.

Key words: angiotensin type 2 receptor blockers, hot weather, hypotension, peripheral vasodilation, sudden collapse.

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