Original Research

The point prevalence of respiratory syncytial virus in hospital and community-based studies in children from Northern Australia: studies in a ‘high-risk’ population

AUTHORS

Gabrielle B McCallum1 PhD, Senior Research Fellow *

Keith Grimwood2 MD, Professor of Infectious Diseases and Paediatrics

Victor M Oguoma3 PhD, Statistician

Amanda J Leach4 PhD, Professor

Heidi C Smith-Vaughan5 PhD, Head of Child Health Laboratory Research and Career Development Fellow

Lesley A Versteegh6 RN, Indigenous Research Nurse

Anne B Chang7 PhD, Divisional Head

AFFILIATIONS

1, 3, 4, 6 Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0811, Australia

2 Gold Coast Health, Gold Coast, Queensland, Australia; Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland Australia; School of Medicine, Griffith University, Gold Coast, Queensland Australia; Department of Respiratory and Sleep Medicine, Queensland Children’s Hospital, Brisbane, Queensland, Australia

5 Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia; School of Medicine, Griffith University, Gold Coast, Queensland Australia

7 Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia; Department of Respiratory and Sleep Medicine, Queensland Children’s Hospital, Brisbane, Queensland, Australia; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia

ACCEPTED: 2 August 2019


early abstract:

Background: Respiratory syncytial virus (RSV) is the leading viral cause of acute lower respiratory infections globally, accounting for high morbidity and mortality burden among children <5-years. As candidate RSV vaccine trials in pregnant women and infants are underway a greater understanding of RSV epidemiology is now needed, especially in paediatric populations with high rates of acute and chronic respiratory disease.

Objective: Toidentify RSV prevalence in children living in northern Australia, a region with a high respiratory disease burden. 

Methods: Data were sourced from 11 prospective studies (four hospital- and seven community-based) of infants and children with acute and chronic respiratory illnesses, as well as otitis media, conducted between 1996-2017 inclusive. The data from northern Australian children in these trials were extracted and, where available and consented, their nasopharyngeal swabs biobanked at -800C were tested by polymerase chain reaction assays for RSV-A and B, 16 other viruses and atypical respiratory bacterial pathogens.         

Results: Overall, 1127 children were included. Their median age was 1.8-years (interquartile range 0.5-4.9); 58% were male, and 90% Indigenous with 81% from remote communities. After human rhinoviruses (HRV), RSV was the second most prevalent virus (15%, 95% confidence interval (CI) 13-18). RSV prevalence was greatest amongst children aged <2-years hospitalised with bronchiolitis (47%; 95%CI 41.4-52.4), with more than two thirds with RSV aged <6-months. In contrast, the prevalence of RSV was only 1-3.5% in other age groups and settings. In one-third of RSV cases, another respiratory virus was also detected. Individual viruses other than RSV and HRV were uncommon (0-9%).

Conclusion: Combined data from eleven hospital and community-based studies of children aged <18-years who lived in communities with a high burden of acute and chronic respiratory illness found RSV was second only to HRV as the most prevalent virus detected across all settings. RSV was the most frequently detected virus in infants hospitalised with bronchiolitis, including those aged <6-months. In contrast, RSV was uncommonly detected in children in community settings. In northern Australia, effective maternal and infant RSV vaccines could substantially reduce RSV bronchiolitis-related hospitalisations, including admissions of Indigenous infants from remote communities.